Allergy immunotherapy | ALK

All about allergy immunotherapy

Targeting the root cause of allergy
Allergy immunotherapy works by giving repeated doses of an allergen, thereby stimulating an immune response in the body which causes the patient to build up an immunological tolerance.

Allergy immunotherapy (AIT) is a causal treatment that addresses the underlying cause of allergies, not just the symptoms, and is the only disease‐modifying treatment for allergic conditions.  

It is the only therapy that has demonstrated the capacity not only to improve symptoms, reduce the need for medications, but also to induce specific tolerance beyond the duration of the treatment and to prevent the development of new allergic conditions. 

AIT involves the repeated administration of specific allergen extracts to an allergic individual. By targeting the specific allergens that trigger a patient’s symptoms, AIT inhibits the occurrence of both seasonal and perennial allergic reactions, to provide long-term relief of symptoms and improvement in their quality of life.

Disease-modifying effect and protective effect

Allergy immunotherapy is the only treatment capable of modifying the course of allergic diseases. AIT treatment course is recommended for 3 to 5 years to achieve a long-lasting sustained effect, where the benefits of treatment continue even after therapy has ended. By inducing immune tolerance, AIT not only relieves symptoms but also potentially prevents the onset of new allergic conditions, something that symptom-relieving medications cannot achieve. AIT also has protective effects on new sensitizations, progression of allergic rhinitis into asthma, and on asthma severity.

The AIT disease-modifying effect

Allergy immunotherapy is the only causal
treatment for allergic disease.

Learn more in this video:

References:

1. Alvaro-Lozano M et al. EAACI Allergen Immunotherapy User's Guide. Pediatr Allergy Immunol. 2020;31 Suppl 25(Suppl 25):1-101

2. Larsen JN et al. Drug Discov Today 2016: 21(1):26-37

3. Shamji M et al. J Allergy Clin Immunol 2017: 140, 1485-1498

4. Durham SR et al. J Allergy Clin Immunol. 2012;129(5):717-725; 2.

5. Valovirta E et al. J Allergy Clin Immunol. 2018;141(2):529-38

6. Penagos M, Durham S. Long-term efficacy of the sublingual and subcutaneous routes in allergen immunotherapy. Allergy Asthma Proc 2022

     43(4):292-298

7. Global Atlas of Allergy, EAACI 2014

Last updated: 05.07.2019